活血化瘀中药联合腹腔镜对轻型子宫内膜异位症不孕患者血清MCP-1,RANTES的影响

Influence of Promoting Blood Circulation to Remove Blood Stasis Combined with Laparoscopy on Serum MCP-1,RANTES in Infertile Patients with Mild Endometriosis

目的:观察活血化瘀中药联合腹腔镜对轻型子宫内膜异位症不孕患者血清单核细胞趋化蛋白-1(MCP-1)、活化调节因子(RANTES)的影响。方法:将50例不孕且经腹腔镜证实为轻型子宫内膜异位症患者随机分为两组,治疗组25例,腹腔镜术后排卵前用丹术消异方治疗,排卵后口服助孕3号丸;对照组25例,腹腔镜术后不予药物治疗。所有患者均于术后B超监测排卵,并指导同房。观察2组患者术后3,6个月的受孕情况;术后6个月复发情况;术后3个月MCP-1,RANTES的变化。结果:①两组患者术后3,6个月妊娠率,流产率经统计学比较,有显著性差异(P<0.05);②术后6个月,两组患者术后复发率,经统计学比较,有显著性差异(P<0.05);③术后3个月,MCP-1,RANTES在治疗组、对照组治疗后均较治疗前明显降低(P<0.05);治疗后治疗组明显低于对照组(P<0.05)。结论:丹术消异方联合腹腔镜手术治疗轻型子宫内膜异位症不孕可提高受孕率,减少复发,其作用机制可能与调节机体免疫,降低血清MCP-1,RANTES水平有关。

Objective： To observe the influence of promoting blood circulation to remove blood stasis combined with laparoscopy on serum monocyte chemotactic protein-1 （ MCP-I ） , activation of regulatory factor （RANTES） in infertile patients with mild endometriosis. Method： Fifty patients were divided into two groups, the treatment group was given traditional Chinese medicine after laparoscope, while the control group was only accepted laparoscopy. The pregnancy rate, recurrence rate, serum MCP-1 and RANTES were observed. Result： The effect in the treatment group was better than that in the control group （P 〈 0.05）. Conclusion： Danzhu Xiaoyi decoction combined with laparoscopy in the treatment of mild endometriosis infertility may improve the pregnancy rate, reduce recurrence rate, its mechanism may be related to the regulation of the immune, and decrease serum MCP-1 and RANTES.