鼻咽癌调强放疗技术的应用和摆位误差探讨

Search for the intensity modulated radiation therapy for nasopharyngeal carcinoma

目的探讨鼻咽癌调强适形放疗精确定位摆位照射技术的应用及可能出现的摆位误差,提高鼻咽癌放疗质量。方法收集我院2010年4月至2011年10月,共59例经病理或MRI诊断证实为鼻咽低分化鳞癌无远处转移患者,采用精确定位摆位和照射技术,全程实行调强放射治疗。治疗前拍摄一次正、侧位验证片,治疗过程中每两周实时验证一次。结果 59例患者积极配合并全部完成全程调强适形放射治疗,放疗结束一月后CT复查,肿瘤消退率100%,仅36例患者出现口干。结论鼻咽癌患者采用调强适形放疗,最大限度地把剂量集中在靶区内,减少了正常组织副反应,提高了肿瘤局部控制率。严格的质量保证和精确的定位摆位可减少摆位误差,是调强放疗成功实施的保证。

Objective To describe the experience of precise setup undergoing the intensity modulated radiation therapy for nasopharyngeal carcinoma and evaluate the possibilities of the setup error and in order to improve the quality of radiation therapy for nasopharyngeal carcinoma. Methods Fifty-nine NPC patients of poorly differentiated squamous cell carcinoma without distant metastases were treated with precise setup and intensity modulated radiation therapy from April 2010 to October 2011.Anteroposterior and lateral pictures were taken before treatment.Then electronic portal images in real time were acquired once every two weeks in the radiation course. Results All the patients had finished the therapy.CT scans were taken one month later after the therapy.The local control rate was 100%.Thirty-six people had dry mouth. Conclusion The intensity modulated radiation therapy aim higher doses of radiation at target region while reducing the radiation to nearby healthy tissue.It can improve the local control rate.Strict quality assurance and precise setup can reduce the setup error and provide better effect of radiation therapy.