益气温阳活血方对慢性心力衰竭患者心室重塑相关因子的影响

Study on the effects of decoction of yiqiwenyanghuoxue on MMPs and cytokines in the patiens with cardiac remodeling

目的观察益气温阳活血方对慢性心力衰竭心室重塑患者血清金属基质蛋白酶2、9(MMP-2、MMP-9)、金属基质蛋白酶抑制物1、2(TIMP-1、TIMP-2)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的影响。方法将慢性心衰患者126例随机分为两组,两组均按慢性心力衰竭治疗指南给予常规治疗,治疗组加服益气温阳活血方。两组治疗前后分别以心脏超声检查患者左心室收缩末径(LVESD),舒张末径(LVEDD)和左心室射血分数(LVEF%),以及酶联免疫吸附法(ELISA)检测血清MMP-2、MMP-9、TIMP-1、TIMP-2、TNF-α、IL-6含量。结果3个月后治疗组LVESD、LVEDD明显缩小,LVEF则明显提高,与治疗前比较,差异有显著性意义(P<0.05)。3个月后患者血清MMP-2、MMP-9、TNF-α、IL-6明显降低,而TIMP-1、TIMP-2、则明显升高,与对照组比较,差异有显著性(P<0.05)。结论益气温阳活血方可降低MMP-2、MMP-9、TNF-α、IL-6含量,升高TIMP-1、TIMP-2含量,防止心室重塑。

Objective To investigate effects of decoction of yiqiwenyanghuoxue on MMPs and in- flammatory cytokines in the patiens with cardiac remodeling. Methods 126 patients with chronic heart failure were randomly divided into two groups which were the control group and treatment group. The control group were given conventional treatment, while the treatment group were decoction of yiqiwe- nyanghuoxue combined routine therapy, then heart function parameters of ultrasonic cradiography and MMP-2, MMP-9,TIMP-1,TIMP-2, TNF-a, and IL-6 were measured before and after treatment. Re- sults After 3 months, LVEDD and LVESD were decreased, while LVEF increased significantly than those of before therapy （P〈~0. 05） . MMP-2, MMP-9, TNF-a, and IL-6 were decreased, whiile TIMP-1 and TIMP-2 increased significantly than those of the control group（P^0.05）. Conclusion De- coction of yiqiwenyanghuoxue can prevent cardiac remodeling through regulating MMP-2, MMP-9, TIMP-1, TIMP-2,TNF-a, IL-6 levels.