羟苯磺酸钙治疗突发性耳聋的临床观察

Clinical Observation of Calcium Dobesilate in the Treatment of Sudden Deafness

目的:观察羟苯磺酸钙治疗突发性耳聋的疗效及对患者血液流变学指标的影响。方法:将我院76例(86耳)突发性耳聋患者随机分成观察组(38例,45耳)和对照组(38例,41耳)。对照组给予三磷酸腺苷二钠、辅酶A、维生素C和维生素B6静脉滴注,并口服双嘧达莫片,同时进行高压氧治疗;观察组在此基础上加服羟苯磺酸钙胶囊治疗。两组的用药时间均为14d。观察两组患者治疗耳聋和耳鸣的疗效以及治疗前、后患者血液流变学指标变化,并比较不良反应。结果:观察组治疗耳聋和耳鸣的总有效率显著高于对照组(P<0.05);观察组患者治疗前、后比较,血液流变学各项指标显著改善(P<0.05或P<0.01),而对照组患者治疗前、后比较,血液流变学各项指标无显著改善(P>0.05),且治疗后两组血液流变学多项指标比较差异有统计学意义(P<0.05),观察组优于对照组;两组患者均未见不良反应发生。结论:羟苯磺酸钙治疗突发性耳聋的临床疗效较好,能使患者血液流变学指标明显改善,且安全性较好。

OBJECTIVE： To observe therapeutic efficacy of calcium dobesilate for sudden deafness and the influence of it on hemorheology parameters. METHODS： 76 patients （86 ears） with sudden deafness were randomly divided into observation group （38 cases, 45 ears） and control group （38 cases, 41 ears）. Control group was given disodium adenosine triphosphate, coenzyme A, vitamin C and vitamin B6 intravenously and Dipyridamole tablet orally; at the same time, received hyperbaric oxygen therapy. Observation group was additionally given Calcium dobesilate capsule on the basis of treatment for control group. Therapeutic effica- cy of therapy for deafness and tirmitus were observed in 2 groups, and the changes of hemorbeology parameters were also ob- served; adverse drug reactions were compared. RESULTS： Total effective rate of observation group was significantly higher than that of control group （P〈0.05） ; the hemorheology parameters of observation group were improved significantly before and after treatment （P〈0.05 or P〈0.01）, while hemorheology parameters of control group had no significant improvement （P〉0.05） ; there was statistical significance in the difference of hemorheology parameters between 2 groups after treatment （P〈0.05） ; no ad- verse drug reaction was found in 2 groups. CONCLUSION： Calcium dobesilate has quite valid curative effect on sudden deafness and can improve hemorheology parameters significantly, showing high safety.