SSRIs和非SSRIs类药物对住院患者焦虑和抑郁情绪改善情况的比较

Discerning the effects of SSRIs and non-SSRIs on levels of anxiety and depression

目的观察SSRIs和非SSRIs类药物对住院患者焦虑和抑郁情绪的改善情况。方法采用焦虑自评量表(SAS)和抑郁自评量表(SDS)对152例某医院心理与心身疾病病房住院患者从入院时每周进行一次SAS和SDS评定,共进行六次评定,分析SSRIs和非SSRIs类药物治疗的疗效差异。结果住院患者从入院第一周至第六周的焦虑和抑郁情绪呈逐渐下降表现;入组时两组焦虑自评量表(SAS)和抑郁自评量表(SDS)评分无显著性差异,治疗第二周时,SS-RIs类药物治疗组SAS、SDS评分均低于非SSRIs类药物治疗组(P<0.01)。在入院时(第一周)和第三至第六周,两组SAS和SDS得分无显著差异。结论无论是SSRIs类还是非SSRIs类药物治疗,住院患者的焦虑和抑郁情绪呈逐渐下降表现,SSRIs类药物治疗只在第二周对改善抑郁和焦虑情绪优于非SSRIs类药物,在入院时和第三至第六周,两组并无明显差异,说明总体上两组疗效无明显差异,对于两周之内需急性改善症状者可优先考虑予以SSRIs类药物治疗。

Objective To compare the treatment effects of selective serotonin reuptake inhibitors （SSRIs） and non - SSRIs in inpatients with anxiety and/or depression. Methods Zung Self - Rating Scale for Depression （SAS） and Zung Self - Rating Scale for Anxiety （SDS） have been used weekly from week - 1 to week - 6 to exam- ine the levels of anxiety among 152 inpatients; comparing the treatment effects of SSRIs and non - SSRIs in those patients. Results We found that levels of anxiety and depression have been stably decreased from week - 1 to week - 6 ; levels of anxiety and depression showed no differences at base line/ （ week - 1 ） ; however, SSRIs group showed lower levels of anxiety and depression than that in non - SSRIs group at week - 2 ; there were no differences in levels of anxiety and depression between SSRIs group and non - SSRIs group at week - 1 and week - 3 to - 6. Conclusion Levels of anxiety and depression have been stably decreased from week - 1 to week - 6 in both SSRIs group and non - SSRIs group ; from week - 1 to week - 6, compared with non - SSRIs group, SSRIs group only showed low levels of anxiety and depression at week - 2 which suggested that SSRIs and non - SSRIs showed no differences of relatively long - term （ sex weeks） treatment effects. The results highlighted that we may select SSRIs for patients who need to relieve the symptoms of anxiety and depression in short time （two weeks）.