大脑老化与神经再生和卒中

Neurogenesis,Stroke and Brain Aging

大脑老化是神经退行性疾病的主要诱因。而卒中不仅是老年人的神经系统常见疾病,而且也是70岁以上老年人致残和死亡的重要原因,因此,大脑老化与卒中发病息息相关。已经证实,老年卒中患者其缺血性脑组织损伤更加严重、脑梗死面积更大、缺血后的神经功能障碍也更加显著。尽管研究已证实老龄大脑的神经再生减少,但卒中可以诱导神经再生并能有效促进神经功能恢复,这就为神经再生治疗卒中开辟了良好的途径。本文重点就大脑老化及老化后神经再生、缺血性卒中作一简要综述。

Brain aging, a common induced factor of neurodegenerative diseases, is associated with a striking increase in the incidence of stroke, which is a common disease of the nervous system and a major cause of disability and death among those aged 70 years and older. It is well documented that there are more serious brain ischemic changes, larger infarction area and more significant nerve dysfunction in elderly. Although many studies have confirmed decreased neurogenesis in aging brain, increased neurogenesis after stroke holds great promise for brain repair. This review seeks to integrate briefly what is known about neurogenesis and ischemic stroke after brain aging.