碱性成纤维细胞生长因子及其受体在甲状腺乳头状癌的表达和意义

Expression and clinical significance of BFGF and BFGFR in papillary thyroid carcinoma

目的探讨碱性成纤维细胞生长因子（BFGF）及其受体（BFGFR）在甲状腺乳头状癌（papillazy thyroid carcinoma，PTC）的表达和相互关系。方法应用免疫组化方法，对2001年3月至2005年5月在中国医科大学附属盛京医院手术并经病理组织学证实的PTC80例，结节性甲状腺肿10例组织标本行BFGF、BFGFR表达研究。结果BFGF及BFGFR阳性表达率在PTC组织中分别为72．5％（58／80）及70．0％（56／80）；在结节性甲状腺肿均为0．0％（0／10），2者相比差异有统计学意义（P〈0．05）；BFGF及BFGFR在PTC中的表达水平与患者性别、年龄、肿瘤大小无关（P〉0．05），与淋巴结转移和UICC定义的肿瘤分期相关（P〈0．05）；BFGF及BFGFR的表达呈正相关（r=0．330，P=0．003）。结论BFGF与BFG—FR在PTC中呈高表达，在结节性甲状腺肿组织无表达；2者在PTC组织中的表达与淋巴结转移和UICC定义的肿瘤分期密切相关，可能参与肿瘤的发生、侵袭和转移。

Objective To study the expression and clinical significance of BFGF factor（BFGF） and basic fibroblast growth factor receptor（BFGFR） in papillary thyroid carcinoma （PTC）. Methods 80 cases of PTC and 10 cases of nodular goiter underwent surgical treatment from Mar. 2001 to May. 2005 in Shengjing Hospital of China Medical University. Samples were collected and immunohistochemistry staining was performed to detect the expression of BFGF and BFGFR. Results The expression rate of BFGF and BFGFR was 72. 5 % （58/80）vs 70. 0% （56/80） in PTC, and 0. 0% （0/10） vs 0. 0% （0/10） in nodular goiter. The difference had statistical significance（P 〈0. 05）. The expression level of BFGF and BFGFR in PTC had no relation with sex, age or tumor size（ P 〉0. 05 ） , but has relation with lymph node metastasis and UICC stage（P 〈0.05）. The expression of BFGF was positively correlated with the expression of BFGFR （ r = 0. 330, P =0. 003 ）. Conclusions BFGF and BFGFR are highly expressed in PTC but have no expression in nodular goiter or normal thyroid tissues. The expression of BFGF and BFGFR in PTC is closely related to lymph node metastasis and UICC stage, indicating the 2 may be involved in tumorigenesis, invasion, and metastasis.