细胞自噬及其与口腔鳞状细胞癌间的相关性

Cell autophagy and its correlation with oral squamous cell carcinoma

细胞自噬是真核细胞程序性死亡的形式之一,广泛存在于包括肿瘤在内的多种病理生理过程中。细胞自噬是一降解系统,可清除细胞内物质,其降解物质供细胞重复利用,对饥饿状态下氨基酸池的维持起着非常重要的作用。口腔鳞状细胞癌与细胞自噬间存在着密切的关系,本文就细胞自噬的分类和功能以及调控机制,细胞自噬的相关基因和蛋白,细胞自噬的诱发因素,细胞自噬与口腔鳞状细胞癌间的关系,细胞自噬与其他肿瘤间的关系等研究进展作一综述。

Cell autophagy is one type of programmed cell death in eukaryotic cells. And it has been widely impli cated in many physiological and pathological processes, including cancer. Cell autophagy is a bulk degradation system, which controls the clearance and re-use of intracellular constituents, and is important for the maintenance of an amino acid pool essential for survival. Recent studies show that cell autophagy is correlated closely to oral squamous cell carcinoma. This review summarizes classifications, functions, regulatory mechanisms and autophagy-related genes and proteins. This review also concentrates on predisposing factors of cell autophagy and the correlation between cell autophagy and oral squamous cell carcinoma and other tumors.