上皮—间质转化诱导因子及其与口腔鳞状细胞癌间的相关性

Inducers of epithelial mesenchymal transformation and its correlation with oral squamous cell carcinoma

上皮—间质转化(EMT)是指上皮细胞失去原有的上皮细胞特性,例如细胞极性丧失、上皮细胞标志物丧失和细胞骨架蛋白改变等而获得间质细胞特性,例如细胞形态转变为梭形、表达α-平滑肌蛋白和迁移侵袭能力增强等过程。EMT在肿瘤的侵袭和转移过程中发挥着重要的作用,本文就EMT信号通路相关因子及其在口腔鳞状细胞癌中作用的研究进展作一综述。

Epithelial--mesenchymal transformation （EMT） can be viewed as the loss of original epithelium cell characteristic, such as loss of polarity, loss of epithelial markers, cytoskeletal reorganization, and transition to a spin- dle-shaped morphology concomitant with acquisition of mesenchymal markers （including a-smooth muscle actin） and an invasive phenotype. EMT plays an important role in the invasion and metastasis of cancer. This article reviews the important inducers of signaling pathways in EMT and highlights recent advances in the studies of signaling pathways in EMT in oral squamous cell carcinoma.