前白蛋白与C反应蛋白在新生儿感染性疾病早期诊断中的临床价值

Clinical values of prealbumin and C reactive protein in early diagnosis of neonatal infectious diseases

目的:探讨前白蛋白(PA)、C反应蛋白(CRP)在新生儿感染性疾病早期诊断中的临床应用价值。方法:以48例新生儿非感染性疾病为对照组,研究348例新生儿感染性疾病PA、CRP检测情况。结果:感染组各种疾病与对照组比较,经q检验分析均有统计学差异(P<0.05),其中PA相对于对照组出现降低,尤其败血症、细菌性肺炎、上呼吸道感染下降较为显著,CRP相对于对照组出现升高,以败血症、细菌性肺炎、上呼吸道感染较为明显;感染组重症感染及普通感染PA、CRP平均浓度经q检验分析均有统计学差异(P<0.05),重症组PA降低、CRP升高比较显著。结论:PA、CRP是评价新生儿感染性疾病早期诊断、病情监测及药物疗效的良好观察指标。

Objective： To explore the clinical application values of prealbumin （PA） and C reactive protein （CRP） in early diag- nosis of neonatal infectious diseases. Methods ： Forty - eight neonates without infectious diseases were selected as control group, the levels of PA and CRP in 348 neonates with infectious diseases were researched. Results： The results of q test showed that there were statistically significant differences in levels of PA and CRP between infection group and control group （ P 〈 0. 05 ）, PA level in infection group de- creased, especially in patients with sepsis, bacterial pneumonia, and upper respiratory tract infection; while CRP level in infection group in- creased, especially in patients with sepsis, bacterial pneumonia, and upper respiratory tract infection. There were statistically significant differences in levels of PA and CRP between patients with severe infection and patients with mild infection in infection group （ P 〈 0. 05 ）, PA level decreased and CRP level increased significantly in patients with severe infection. Conclusion： PA and CRP are good observational in- dexes to evaluate early diagnosis, illness monitoring, and curative effect of infectious diseases among neonates.