宫颈鳞癌组织中Ki-67和P53的表达及其意义

Expressions and clinical significances of Ki-67 and P53 in cervical squamous cell carcinoma

目的:探讨宫颈鳞癌组织中Ki-67和P53蛋白的表达及其与临床病理特征的关系。方法:采用免疫组织化学技术,检测60例子宫颈鳞癌、40例宫颈原位癌(CINⅢ)和20例癌旁正常宫颈上皮(NCE)中Ki-67和P53的表达,分析其表达与宫颈鳞癌的临床分期、病理类型及有无淋巴结转移的关系。结果:Ki-67在宫颈鳞癌、原位癌和NCE中的阳性表达率分别为78.33%、52.50%、35.00%;P53为71.67%、55.00%、0.00%。NCE组与鳞癌组及原位癌组相比较差异均有统计学意义(P<0.01)。Ki-67和P53的阳性表达率与临床分期、病理类型及有无淋巴结转移均有明显相关性(P<0.01);Ki-67和P53在宫颈鳞癌的表达中呈正相关(P<0.01)。结论:Ki-67和P53在宫颈癌组织中表达水平的上调可能在宫颈鳞癌浸润和转移中起重要作用。

Objective： To explore the relationship between expressions of Ki -67and P53 in cervical squamous cell carcinoma and the elinieopathological characteristics. Methods： Immunohistochemical method was used to detect the expression levcls of Ki - 67 and P53 in 60 cases with cervical squamous cell carcinoma, 40 cases with cervical carcinoma in situ （ CIN m ） and 20 cases with normal cervical epi- thelium adjacent to earcinoma （NCE） . The relationship between their expression levels and clinical stages, pathological types, and lymph node metastasis or not was analyzed. Results： The positive expression rates of Ki - 67 in cervical squamous cell carcinoma, cervical carcino- ma in situ and NCE were 78.33% , 52. 5% , and 35.00%, respectively; the positive expression rates of P53 in cervical squamous cell carci-noma, cervical carcinoma in situ, and NCE were 71.67% , 55.00% , and 0. 00%, respectively. There were statistically significant differences in positive expression rates of Ki - 67 and P53 between NCE group and cervical squamous cell carcinoma group, cervical car- cinoma in situ group （P 〈0. 01 ） . There was a significant correlation between positive expression rates of Ki -67 and P53 and clinical sta-ges, histological types, and lymph node metastasis （P 〈 0. 01 ） . There was a positive correlation between Ki - 67 expression and P53 ex- pression in cervical squamous cell carcinoma （P 〈 0. 01 ） . Conclusion： Up - regulation of Ki -67 and P53 in cervical squamous cell car- cinoma may play an important role in invasion and metastasis of cervical squamous cell carcinoma.