C型尿钠肽在动物繁殖过程中的作用研究进展

Advances on the Role of C-type Natriuretic Peptide in Regulating Animal Reproduction Processes

C型尿钠肽(CNP)为尿钠肽家族成员之一,作为自分泌及旁分泌因子不仅具有维持心血管系统功能稳态、调控细胞增殖及促进骨骼生长等功能,并且在动物繁殖过程方面具有重要的作用。近年研究揭示CNP是小鼠体内减数分裂抑制物质,而且CNP能够促进卵泡发育,增加促性腺激素刺激后的排卵数量。基于此,CNP在用作生理性的减数分裂抑制剂增强卵母体外发育及提高家畜的超排效率方面具有重要的应用前景。因此,综述CNP结构、作用机制、在动物繁殖过程的作用及应用前景。

C-type natriuretic peptide （ CNP ） , a member of the natriuretic peptide family of structurally related peptides, is a autocrine / paracrine growth factor with important roles in cardiovascular homeostasis, regulation of cell proliferation and skeletal development ; moreover, CNP also plays a key role in modulating animal reproductive processes. Notably, recent studies have revealed that CNP acts as a regulator to inhibit meiotic resumption in mouse oocytes in vivo ; additionaUy, CNP can enhances superovulation response by the stimulation of follicular development prior to gonadotropins treatment. In light of the findings above, CNP may be of special importance in the promotion of oocyte development in vitro as one meiotic inhibitor, as well as the improvement of superovulation efficiency in domestic animals. Hence, this paper reviewed the structure of CNP, its role as one of functional molecules that modulate reproductive processes in animals and its potencial value.