松针总黄酮抗氧化调血脂作用研究

Total Flavonoids of Pine Needle for Regulating Blood Lipid and Resisting Lipid Peroxidation

目的:探讨松针总黄酮对饮食诱导肥胖大鼠肝脏自由基和血脂代谢的影响。方法:以高糖高脂饮食诱导肥胖大鼠造成氧化应激状态和脂代谢紊乱,松针总黄酮灌胃给药,测定血脂水平和肝匀浆中抗氧化酶系活性、MDA含量,评价松针总黄酮抗氧化调血脂作用。结果:松针总黄酮能提高肝脏抗氧化酶活性,降低MDA含量。结论:松针总黄酮可显著改善肥胖大鼠的氧化应激状态,并具有调血脂作用。

Objective：To investigate the total flavone of pine needle on diet induced obese rat liver free radical and lipid metabolism.Methods： High-glucose and high-fat diet induced obese rats caused by oxidative stress and lipid metabolism disorder,total flavone of pine needle intragastric administration,determination of the antioxidant enzyme activity and the content of MDA in liver homogenate and blood lipid level evaluation of the effect on regulating blood lipid and resisting lipid peroxidation by total flavone.Results：The total flavone of pine needles could improve myocardial oxidative enzymes in liver homogenate activity,reduce LDL-C,VLDL-C,TG,TC and the content of MDA.Conclusion：The total flavone of pine needle has an effect on regulating blood lipid and resisting lipid peroxidation.