有无家族史抑郁症患者认知电位P300的比较

The comparison of cognitive potential P300 in major depressive disorder between with and without family history

目的 探讨有家族史与无家族史抑郁症患者认知电位P300的特点.方法 选取重性抑郁障碍患者无家族史与有家族史各67例为研究组,选取同期健康志愿者67例为对照组,对所有研究对象进行认知电位P300的检测.结果 ①3组间N2潜伏期差异有统计学意义（P＜0.05）;其中有家族史抑郁症患者N2潜伏期[（208.40 ±33.05） ms]较无家族史者[（193.55±40.01）ms]及正常组[（189.33±51.13）ms]明显延长,差异具有统计学意义（P＜0.05）.②与正常对照组[ （3.38±5.52） μV]相比,无家族史组[ （2.47±1.87） μV]与有家族史组[（2.36±2.10） μV] N2波幅均明显降低,差异有统计学意义（P＜0.05）,但未发现二组间有明显差异（P＞0.05）.结论 有家族史与无家族史抑郁症患者均存在认知功能损害,且有家族史者受损更明显.

Objective To explore the character of cognitive potential P300 in major depressive disorder （ MDD ） patients between with and without family history and compare the cognitive function between them.Methods Sixty-seven MDD patients with family history and sixty-seven MDD patients without family history were assigned to research group,sixty-seven healthy volunteers were assigned to control group,and ERP P300 detections were conducted in all subjects.Results ①To compare with control group （ （ 189.33 ± 51.13 ） ms） and MDD without family history group（ （ 193.55 ± 40.01 ）ms）,the N2 latency was prolonged more significantly in MDD with family history group （ （ 208.40 ± 33.05 ） ms ） （P 〈 0.05 ）.②Compared with control group （ （ 3.38 ± 5.52 ） μV ）,the N2 amplitude was decreased more significantly in MDD without （ （ 2.47 ± 1.87 ） μV ） and with family history （ （ 2.36 ± 2.10） μV ）,（P 〈 0.05 ）.Conclusion There is an obvious cognitive function damaged in the MDD patients with and without family history and the MDD patients with family history are more serious.