摘要
目的 探讨有家族史与无家族史抑郁症患者认知电位P300的特点.方法 选取重性抑郁障碍患者无家族史与有家族史各67例为研究组,选取同期健康志愿者67例为对照组,对所有研究对象进行认知电位P300的检测.结果 ①3组间N2潜伏期差异有统计学意义(P<0.05);其中有家族史抑郁症患者N2潜伏期[(208.40 ±33.05) ms]较无家族史者[(193.55±40.01)ms]及正常组[(189.33±51.13)ms]明显延长,差异具有统计学意义(P<0.05).②与正常对照组[ (3.38±5.52) μV]相比,无家族史组[ (2.47±1.87) μV]与有家族史组[(2.36±2.10) μV] N2波幅均明显降低,差异有统计学意义(P<0.05),但未发现二组间有明显差异(P>0.05).结论 有家族史与无家族史抑郁症患者均存在认知功能损害,且有家族史者受损更明显.
Objective To explore the character of cognitive potential P300 in major depressive disorder ( MDD ) patients between with and without family history and compare the cognitive function between them.Methods Sixty-seven MDD patients with family history and sixty-seven MDD patients without family history were assigned to research group,sixty-seven healthy volunteers were assigned to control group,and ERP P300 detections were conducted in all subjects.Results ①To compare with control group ( ( 189.33 ± 51.13 ) ms) and MDD without family history group( ( 193.55 ± 40.01 )ms),the N2 latency was prolonged more significantly in MDD with family history group ( ( 208.40 ± 33.05 ) ms ) (P 〈 0.05 ).②Compared with control group ( ( 3.38 ± 5.52 ) μV ),the N2 amplitude was decreased more significantly in MDD without ( ( 2.47 ± 1.87 ) μV ) and with family history ( ( 2.36 ± 2.10) μV ),(P 〈 0.05 ).Conclusion There is an obvious cognitive function damaged in the MDD patients with and without family history and the MDD patients with family history are more serious.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2012年第8期699-701,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
山西省青年科技研究基金项目(2010021036-3)
山西省科技攻关项目(20110313012-1)