晚发性抑郁症患者前瞻记忆研究

A study of prospective memory in patients with late-onset depression

目的 研究晚发性抑郁症患者基于事件前瞻记忆（EBPM）和基于时间前瞻记忆（TBPM）的特征,明确基于事件前瞻记忆（EBPM）和基于时间前瞻记忆（TBPM）在晚发性抑郁症患者中的损害情况,探讨患者前瞻记忆与其临床症状的关系.方法 对32例晚发性抑郁症患者以及年龄、性别、受教育程度相匹配的30名正常对照者实施前瞻记忆测试,并用17项汉密尔顿抑郁量表评估患者的临床症状.结果 与正常对照组[EBPM：（3.07±0.87）分、TBPM：（2.67±0.92）分]相比,患者组的EBPM评分[（2.31±1.06）分]和TBPM评分[（2.03±0.93）分],差异有统计学意义（t=- 3.052,P＜0.01;t=- 2.695,P＜0.01）.相关分析显示,患者EBPM和TBPM评分与汉密尔顿抑郁量表总分呈负相关（r=- 0.436,P=0.013;r=-0.467,P=0.007）.结论 晚发性抑郁症患者基于事件前瞻记忆和基于时间前瞻记忆均存在损害,患者前瞻记忆与其临床症状存在相关性.

Objective To investigate the event-based prospective memory （EBPM）and time-based prospective memory（ TBPM ）in late-onset depressive patients and to explore the relationships between prospective memory and depressive symptoms.Methods 32 late-onset depressive patients and 30 normal controls matched in age,gender and education were assessed with a neuropsychological battery of tests including EBPM and TBPM tasks.The patients were also assessed with Hamilton Depression Scale （HAMD）.Results A statistically significant in EBPM was observed between patients with late-onset depression and normal controls （2.31 ± 1.06 vs 3.07± 0.87,t =- 3.052,P 〈 0.01） and the same result in TBPM （2.03 ± 0.93 vs 2.67 ± 0.92,t =- 2.695,P 〈0.01 ）.The negatively correlate was showed between the total scores of HAMD and EBPM （ r =- 0.436,P =0.013 ）,TBPM （ r =- 0.467,P =0.007 ） in the patients.Conclusion The results suggest late-onset depressive patients impair both EBPM and TBPM.Prospective memory shows correlation with depressive symptoms in the patients.