慢性肾脏病患者静息心率与颈动脉病变的关系

Relationship between resting heart rate and carotid atherosclerosis in chronic kidney disease

目的探讨非透析慢性肾脏病(CKD)患者静息心率(RHR)与颈动脉病变的关系。方法将非透析CKD患者102例按RHR值分为3组:RHR 1组33例(RHR<70次/分)、RHR 2组35例(RHR 70～79次/分)和RHR 3组34例(RHR≥80次/分),应用颈动脉超声检测3组患者颈动脉内膜中层厚度(IMT)、斑块形成及颈动脉硬化的患病率。结果 3组CKD患者的颈动脉IMT、斑块形成及颈动脉硬化的患病率比较差异均有统计学意义(P<0.05或P<0.01);随着RHR的逐渐增高,颈动脉IMT、斑块形成及颈动脉硬化的患病率也逐渐增高,各组间比较差异有统计学意义(P<0.05或P<0.01);相关分析显示,RHR与颈动脉IMT、斑块形成及颈动脉硬化的患病率呈正相关(P<0.05或P<0.01)。结论非透析CKD患者的RHR增高与颈动脉病变相关,提示,RHR的增高是CKD患者并发动脉粥样硬化的危险因素之一。

Objective To investigate the relationship between resting heart rate（RHR） and atherosclerosis in patients with non-dialytic chronic kidney disease（CKD）.Methods According to the RHR,102 cases were divided into three groups,RHR 1 group（n=33,RHR70 beats/min）,RHR 2 group（n=35,70≤RHR79 beats/min） and RHR 3 group（n=34,RHR≥80 beats/min）.The carotid intima-media thickness（IMT） and prevalence of atherosclerosis were detected with carotid ultrasonography in the three groups.Results The differences of carotid IMT,carotid atherosclerotic plaque and prevalence of atherosclerosis were significant among the three groups（P0.05 or P0.01）.Carotid IMT and prevalence of atherosclerosis increased significantly following the increasing RHR（P0.05 or P0.01）RHR was positively related with carotid IMT and prevalence of atherosclerosis（P0.05 or P0.01）.Conclusion Higher resting heart rate is associated with increased prevalence of atherosclerosis in non-dialytic CKD patients,indicating that RHR is independent risk factor of the atherosclerosis in CKD.