青少年原发性干燥综合征23例临床分析

Clinical features of primary Sjogren's syndrome in younger patients

目的探讨青少年(≤30岁)原发性干燥综合征(primary Sjogren Syndrome,pSS)的临床特点。方法回顾性分析2009年9月—2011年7月于南京鼓楼医院风湿免疫科住院的23例pSS患者的临床特点。结果 23例pSS患者中女性22例,男性1例,平均年龄(23±4)岁,平均病程(6±6)个月。首发症状为口干和/或眼干占30%;其余血液系统损害(7/16),发热(4/16),腮腺肿大(1/16),胸闷(1/16),皮疹(1/16),双下肢麻木(1/16),关节痛(1/16)。结论青少年pSS发病患者中,女性多见,2/3以非口干眼干为首发症状,系统损害发病率高,其中血液系统受累多见。

Objective To investigate the clinical features of primary Sjogren＇s syndrome（pSS） in younger patients（age≤30）.Methods The clinical features and laboratory indices of 23 younger pSS patients were collected in The Drum Tower Hospital from September 2009 to July 2011.And the data were retrospectively analyzed.Results There were 22 females and one male.The mean age was（23±4） years old,and the average disease duration was（6±6） months.The percentage of dry mouth/eye as an onset symptom was 30%.Other involvements were hematological system（7/16）,fever（4/16）,swelling of parotid gland（1/16）,dyspnea（1/16）,erythra（1/16）,numbness on both lower extremities（1/16） and arthralgia（1/16）.Conclusion Younger pSS patients are almost famales,and 2/3 of the symptoms are dry mouth/eye as onset symptoms.The incidence of system involvement is high especially the hematological system.We should think over and think highly of the above symptoms in clinical work.