268例丙戊酸血药浓度监测结果分析

Serum concentration monitoring on valprosic acid:an analysis of 268 cases

目的对268例丙戊酸血药浓度监测结果进行分析,为临床用药提供科学依据,促进丙戊酸的合理使用。方法采用荧光偏振免疫法(FPIA)对服用丙戊酸制剂的患者进行血药浓度监测,并对其监测结果进行统计分析。结果 165例在50～100mg·L-1,占总数61.57%,儿童患者的血药浓度相对偏高。结论丙戊酸的血药浓度存在个体差异,对其进行血药浓度监测结合临床疗效为患者提供个体化给药。

Objective To promote the rational use for valproic acid and to provide scientific basis for clinical usage of it by analyzing the results of 268 cases of monitoring serum concentration of valproic acid.Methods The serum concentration of valproic acid was monitored by the fluorescence polarization immunoassay（FPIA）and the results were analyzed.Results A total of 165 cases of serum concentration（about 61.57% of the whole）were in 50~100 mg·L-1.The average serum concentration of children were relatively higher.Conclusion There is distinct difference in serum concentration of valproic acid in different patients,so it is necessary to prescribe individually by monitoring the serum concentration and the clinical effects.