缬沙坦对原发性高血压患者左心室肥厚和心率变异性的影响

The Effects of left ventricular hypertrophy reversion and heart rate variability with treatment of Valsartan in patients with primary hypertension

目的探讨和分析缬沙坦对原发性高血压患者左心室肥厚和心率变异性的影响。方法收集2009年1月至2012年6月在我院心内科采用缬沙坦单药治疗原发性高血压患者90例,对其临床资料进行分析并随访6月,观察治疗前后患者血压、左心室肥厚和心率变异性的变化。结果治疗后,血压与治疗前相比下降明显;评价左心室肥厚的3项指标与治疗前相比明显降低;评价心率变异性的4项指标与治疗前相比明显升高,治疗前后各数据比较均具有统计学差异。结论缬沙坦降压效果确切,且能够逆转患者左心室肥厚,改善心率变异性。

Objective To discuss and analysis the influence of left ventricular hypertrophy reversion and heart rate variability with treatment of valsartan in patients with primary hypertension.Methods The present study was conducted in the department of cardiology in bozhou people＇s hospital,90 patients were consecutively recruited from January 2009 to June 2012 and follow-up 6 months.All patients was evaluated carefully for their eft ventricular hypertrophy,blood pressure and heart rate variability before and after treatment.Results blood pressure,the index of left ventricular hypertrophy and heart rate variability,all of those index were improved significantly compare with pro-treatment,there was statistically significant diffierence between the two groups（P0.05）.Conclusions Valsartan has the significantly antihypertensive effect and can reverse left ventricular hypertrophy,improve heart rate variability.