老年人群代谢综合征与骨密度的相关性研究

Correlation between metabolic syndrome and bone mineral density in senior patients

目的探讨老年人群代谢综合征(MS)与骨密度(BMD)的相关性。方法选取老年男性健康体检病例460例,计算体质量指数(BMI),测量血压,检测空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),并测定骨密度参数(T值和Z值),分析老年人群代谢危险因素和骨密度的相关性。结果 MS组与非MS组相比,BMI、收缩压(SBP)、舒张压(DBP)、FBG、TG、骨密度T值和Z值均偏高(t=11.708、5.718、5.784、8.104、11.309、2.429、2.135,均P<0.05),HDL-C偏低(t=8.120,P<0.05);骨密度与BMI成正相关(r=0.219,P<0.05),与年龄成负相关(r=-0.219,P<0.05)。结论代谢综合征患者肥胖对骨密度有保护作用。

Objective To investigate the relationship between metabolic syndrome （MS）and bone mineral density in senior patients. Methods To selected 460 senior male patients with health examination. The body mass in- dex （BMI） and blood pressure were determined or calculated. The levels of fasting blood-glucose （FBG） ,total cho- lesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） were measured. Bone mineral density index （T and Z） were detected. The correlation of BMD with other metabolic risk factors was analyzed. Results In comparison with without MS, the levels of BMI, systolic blood pres- sure （ SBP）, diastolic blood pressure （ DBP）, FBG, TG, T and Z score were higher （ t = 11. 708,5. 718,5. 784, 8. 104,11. 309,2. 429 or 2. 135, P 〈 0.05 ）, while serum HDL-C level was lower in MS （ t = 8. 120, P 〈 0.05 ）. Spearman analysis showed that BMD was positively correlated with BMI （r = 0. 219 ,P 〈 0.05 ）, and was negatively correlated with age （ r = - 0. 219, P 〈 O. 05 ）. Conclusion The obesity of MS has beneficial effect to BMD.