丹红注射液对老年不稳定型心绞痛患者的抗血栓治疗研究

Antithrombotic study of Danhong Injection in the treatment of old patient with unstable angina pectoris

目的研究丹红注射液对老年不稳定型心绞痛患者血栓相关指标的影响,探讨丹红注射液在老年心血管疾病患者中的临床应用价值及安全性。方法 130例老年不稳定型心绞痛患者随机分为研究组(80例)和对照组(50例),研究组在常规治疗基础上加用丹红注射液,对照组在常规治疗基础上加用前列地尔注射液。结果研究组与对照组均能降低花生四烯酸(AA)和二磷酸腺苷(ADP)诱导的血小板聚集率,与对照组比较,研究组显著降低ADP诱导的血小板聚集率(P<0.01);还可显著降低D-二聚体含量和血浆纤维蛋白原含量(P<0.01)。结论丹红注射液可抑制老年不稳定心绞痛患者血小板聚集、降低血纤维蛋白原从而降低血栓形成风险。

Objective To investigate the antithrombotic effects and safety of Danhong Injection （DHI） in patients with unstable angina pectoris and detect the possible mechanisms. Methods 130 patients with unstable angi- na pectoris were randomized to trial group （80 cases） and control group （50 cases）. All were administered with rou- tine medication. Additionally, DHI was administered intravenously to patients in the trial group. The changes in plasma biochemical indicators were monitored. Results There was a significant difference in the inhibition rate of the ADP and AA induced platelet aggregation in each group after treatment. The difference of the ADP induced platelet aggre- gation rate was statistically significant between the two groups （P 〈 0.01 ）, but not for AA induced platelet aggregation rate. The plasma levels of fibrinogen and D-dimmer in the treatment group were significantly decreased after treatment compared with the control group （P 〈0.01 ）. No abnormal changes in blood routine examination,liver or renal func- tions were seen in all patients. Conclusion DHI is proved to be an effective and safe agent to the patients with unsta- ble angina pectoris.