抗肿瘤小分子多肽的研究进展

Research Progress on Small-Molecule Antitumor Peptides

抗肿瘤小分子多肽具有分子量小、低毒性、高活性、易于穿透肿瘤细胞等特点,一些抗肿瘤小分子多肽已进入临床研究,成为肿瘤药物研发的新热点。本文从抗肿瘤小分子多肽的不同来源途径、结构改造及生物活性等方面,对其近年来的研究进展作简要概述。

Antitumor peptides have the characteristics of small molecular weight,low toxicity, high activity, easily penetrating the tumor cells. Small-molecule antitumor peptides have entered clinical research, becoming the new hotspot of cancer drug development. In this paper, small-molecule antitumor peptides from different sources are summarized according to their structure transformation and biological activity.