聚乙二醇和叶酸对层状双金属氢氧化物颗粒的表面修饰

Surface Modification of Layer Double Hydroxide Particles by Poly(ethylene glycol) and Folic Acid

以具有伪装隐形作用的聚乙二醇(PEG)和具有靶向作用的叶酸(FA)为修饰剂,以氨丙基三甲氧基硅烷(APTMS)为连接剂,对Mg3Al-NO3层状双金属氢氧化物(LDH)进行了表面修饰,制备了LDH-PEG-FA纳米颗粒,并通过X射线衍射(XRD)、透射电子显微镜(TEM)、紫外-可见光谱(UV-Vis)、傅里叶变换红外光谱(FTIR)、粒度分布分析和元素分析等技术对其结构进行了表征.结果表明,PEG和FA的修饰量可由其原料配比调控,修饰后的产物具有良好的水再分散性,这主要源于修饰层的空间位阻效应.预期LDH-PEG-FA同时具有伪装隐形性和靶向性,可用于药物载体等领域.

Using（3-aminopropyl）trimethoxy silane（APTMS） as linker agent,the Mg3Al-NO3 layer double hydroxides（LDH） particles surface were modified by poly（ethylene glycol）（PEG） with disguise function and folic acid（FA） with targeted function.The obtained surface modified LDH particles（LDH-PEG-FA） were characterized by X-ray diffraction（XRD）,transmission electron microscope（TEM）,UV-Vis spectrometer,Fourier transform infrared spectrometer（FTIR）,laser particle size analyzer and elemental analysis（EA）,respectively.The results show that the surface modification of LDH particles can be controlled by the variation of the amount of PEG and FA used in raw materials.Particularly,the modified products exhibit good water re-dispersibility which is mainly attributed to the space steric effect of the modified layers.As the characteristic of disguising and targeting,the LDH-PEG-FA is expected to be used in drug delivery field.