益生菌辅助防治过敏性疾病的研究进展

The research progress on adjuvant therapy of allergic disease by probiotics

益生菌是一类在适当的摄入数量时会对宿主机体带来益处的活体微生物,其对于机体的免疫系统具有调节作用。研究表明,益生菌可以通过调节Th1/Th2平衡,增加宿主对相关抗原的口服耐受,从而缓解过敏性症状。本文综述了近十年来研究益生菌抗过敏作用在体外试验、动物实验和临床试验三方面的进展。

Probiotics are defined as live microorganisms that, when administered in adequate amount can confer a health benefit on the host and regulate the immune system. Accumulated evidence has been demonstrated the alleviation of allergic symptoms by probiotics was conducted via regulation of Thl/Th2 balance as well as the improvement of oral tolerance of the hosts. In this paper, the research progresses in last decade in the anti-allergic effect ofprobiotics in vitro tests, in experimental animals as well as clinical trials are reviewed. It is shown probiotics is of great potentials in adjuvant treatment of allergic diseases.