冠心病患者微量白蛋白尿与可溶性糖基化终产物受体的关系研究

Relationship Between Microalbuminuria and Soluble Glycation End-Product Receptor Levels in Patients With Coronary Artery Disease

目的:研究冠心病患者微量白蛋白尿(MAU)与可溶性糖基化终产物受体(sRAGE)的关系。方法:纳入符合标准的149例患者,根据冠状动脉造影结果分为冠心病组(n=99)和非冠心病组(n=50);并将99例冠心病患者按照有无MAU分为冠心病MAU亚组(n=26)和冠心病非MAU亚组(n=73);比较各组间sRAGE的水平,并使用logstic回归进行分析,观察冠心病患者MAU与sRAGE的关系。结果:sRAGE各组间比较:冠心病组(732.6±133.2)明显低于非冠心病组(1055.5±279.5),冠心病MAU亚组(655.3±121.4)明显低于冠心病非MAU亚组(760.1±127.0),差异均有统计学意义(P均<0.001)。logistic回归分析显示:MAU与sRAGE明显负相关(P=0.018,95%可信区间0.992～0.999)。结论:冠心病患者MAU水平与sRAGE明显负相关,sRAGE可能是预测冠心病患者风险的新型生物标志物。

Objective ：To study the relationship between microalbuminuria（MAU） and soluble glycation end-product receptor（sRAGE） levels in patients with coronary artery disease （CAD）. Methods ： A total of 149 patients were enrolled and defined into 2 groups according to coronary angiography diagnosis as Non- CAD group, n = 50 and CAD group, n = 99. CAD group were further divided into MAU＋sub-group, n = 26 and MAU-sub-group, n = 73. Plasma levels of sRAGE were examined and compared among different groups. Logistic regression analysis was performed to observe the relationship between MUA and sRAGE levels in CAD patients. Results ： sRAGE level in CAD group （ 732. 6 ± 133.2 ） was much lower than that in Non-CAD group （ 1 055.5± 279. 5 ） ; sRAGE level in MAU ＋ sub-group （ 655.3 ± 121.4） was much lower than that in MAU--sub-group （ 760. 1± 127. 0 ）, all P〈0. 001. Logistic regression analysis showed that plasma MAU level was negatively related to sRAGE,P〈0. 018,95% CI 0. 992-0. 999. Conclusion：MAU was significantly and negatively related to plasma sRAGE, it may work as a novel biomarker for risk predicting in CAD patients.