高密度脂蛋白亚组分促胆固醇逆转运及抗氧化功能研究

Research for Promoting Reverse Cholesterol Transportation and Anti-Oxidation Function ofHigh Density Lipoprotein Sub Classes in ACS Patients

目的:明确急性冠状动脉(冠脉)综合征(ACS)患者高密度脂蛋白(HDL)亚组分(HDL2和HDL3)的促胆固醇逆转运及抗氧化功能是否发生了损害;同时探讨HDL2和HDL3抗动脉粥样硬化作用的强弱。方法:入选年龄及性别匹配的ACS患者(ACS组)及健康体检者(对照组)各40例,分别检测两组血脂四项、高敏C-反应蛋白、巨噬细胞氚三胆固醇转出率、脂氢过氧化物(LOOH)水平。结果:与对照组比较,ACS组HDL亚组分(HDL2和HDL3)介导的巨噬细胞氚三胆固醇转出率均明显下降;HDL亚组分LOOH水平则均较对照组明显升高;对照组和ACS组同组内,HDL3介导的巨噬细胞氚三胆固醇转出率均低于HDL2,HDL3-LOOH水平高于HDL2-LOOH。上述比较差异均有统计学意义(P<0.05～0.001)。结论:ACS患者HDL亚组分促胆固醇逆转运及抗氧化功能受到了损害,较对照组明显减弱;成熟的HDL2较未成熟的HDL3具有更强的促胆固醇逆转运及抗氧化功能。

Objective ： To explicit the possible impairments of promoting reverse cholesterol transportation （RCT） and anti-oxidation function of high density lipoprotein（HDL） sub classes（ HDL2 and HDL3 ）in patients with acute coronary syndromes（ACS） and to explore the functional difference between I-IDL2 and HDL3. Methods ：There were 2 groups enrolled in our study, ACS group and Healthy control group, n = 40 in each group. Plasma lipids and HDL sub classes of HDL2 and HDL3, hs-CRP Levels, cholesterol efflux capacity and LOOH levels were examined and compared between 2 groups. Results：Compared with Healthy control group, the HDL2 and HDL3 in ACS group showed decreased cholesterol efflux capacity and increased LOOH level. Within ACS group, the cholesterol efflux capacity in HDL3 was lower than that in HDL2 ,while the HDL3-LOOH level was higher, P〈0.05 -0.001 respectively. Conclusion：RCT and anti-oxidation functions of I-IDL2 and HDL3 were impaired in ACS patients, and those functions were strouger in HDL2 than that in HDL3.