益气活血化瘀汤对慢性心力衰竭大鼠心肌组织AngⅡ、BNP的影响

Qi and blood circulation decoction on chronic heart failure in rat plasma Ang Ⅱ,BNP

目的:观察益气活血化瘀汤对慢性心力衰竭大鼠血清脑钠素(BNP)、血管紧张素Ⅱ(AngⅡ)的影响,探讨其防治慢性心衰的作用机制。方法:以冠脉结扎法配合力竭式游泳、减食等造成大鼠慢性心衰动物模型;将大鼠分为正常组、模型组、西药组及中药组。西药组灌服卡托普利50 mg/(kg.d),中药组灌服益气活血化瘀汤9g/(kg.d);其它两组分别灌服等量生理盐水,治疗结束后测定血清中AngⅡ及BNP的水平。结果:模型组血清BNP和AngⅡ的水平较正常组显著升高,具有统计学意义;给以益气活血化瘀中药治疗后其水平均明显降低,其治疗效果与西药组疗效相当。结论:冠状动脉结扎法可成功复制实验性慢性心衰模型;益气活血化瘀汤能够降低血清BNP、AngⅡ水平,这可能是其防治慢性心衰的作用机制之一。

Objective： To observe the Qi and blood circulation decoction on chronic heart failure rat serum brain natriuretic peptide （BNP）, angiotensin II （Ang II）, and to explore its mechanism of prevention and treatment of chronic heart failure. Coronary ligation with exhaustive swimming, caused by food and other animal models of rats with chronic heart failure; rats were divided into normal group, model group, the WM group and TCM group. Western medicine group irrigation service captopril 50 mg / （ kg . d）, Chinese medicine group fed with Qi and blood circulation soup 9 g / （ kg. d） ; other two groups were fed with normal saline, after the end of treatment serum Ang Ⅱ and BNP levels. The model group serum BNP and Ang II level than the normal group significantly increased, with statistical significance; give Qi and traditional Chinese medicine treatment were significantly lower, the efficacy of its treatment with Western medicine group. Conclusion： coronary artery ligation can be successfully copied experimental chronic heart failure model; Qi and blood circulation soup can reduce the serum of BNP and Ang Ⅱ levels, which may be one of the mechanisms of prevention and treatment of chronic heart failure.