华蟾素联合光动力学法直肠给药对载承黏膜的影响

Influence of Cinobufotalin Combined with Photodynamic Method on Rectal Mucosa

目的:观察抗肿瘤药物华蟾素联合研究光动力疗法直肠给药对载承黏膜的影响。方法:用华蟾素联合新型光敏剂甲酯化叶绿素(MECD)治疗移植性H22肝癌和单一使用华蟾素及PDT作比较,观察抑瘤率及直肠黏膜的病理改变。结果:PDT联合华蟾素组、华蟾素组、PDT组的抑瘤率分别为,H22:51.69%、33.49%、26.50%,病理提示MECD光敏剂直肠给药对载承黏膜有一定损伤,但未见明显血便。结论:华蟾素联合MECD光敏剂直肠给药方式疗效可靠,无明显不良反应,是有可行意义值得提倡推广。

Objective ： To observe the united effects with the combined anti - tumor drugs of Cinobufacin and photodynamic therapy to the mucosa of rectum. Methods ： new photosensitizer methyl esterification of chlorophyll （MECD） combining with Cinobufotalin treat Transplanted H22 liver cancer and single use of PDT and/or Cinobufotalin to observe The inhibiting tumor rates and the pathological changes of rectal mucosa. Results： inhibitory rate of PDT Joint Cinobufotalin Group, cinobufotalin group, PDT group is 51.69% ,33.49% ,26.50%. Although the pathology results suggest that some damage to the mucosa of rectum with the MECD , but no bloody stools. Conclusion： Experiments show that this method is effective and reliable, remarkable side effects were seen. Tthere is a practical significance and deserves recommendation.