卡维地洛治疗充血性心力衰竭伴心房颤动疗效观察

Effective observation of carvedilol in treatment of congestive heart failure complicating atrial fibrillation

目的探讨卡维地洛治疗充血性心力衰竭伴心房颤动的疗效。方法筛选2006年8月至2011年11月收治的充血性心力衰竭伴心房颤动患者102例,随机分为卡维地洛组和对照组,卡维地洛组56例,对照组46例。对照组根据患者病情给予常规治疗(强心苷类、利尿药、血管紧张素转换酶抑制剂等),卡维地洛组在常规治疗基础上加用卡维地洛(2.50～20.00 mg,每天2次),分别治疗6个月,定期随访,比较治疗前后患者临床指标变化,评估其临床有效性。结果两组患者总有效率比较,差异有统计学意义(P<0.05);卡维地洛组患者治疗后平均心室率显著低于对照组,差异有统计学意义(P<0.05)。结论卡维地洛能够显著改善充血性心力衰竭伴心房颤动患者的临床症状,降低心室率。

Objective To investigate the effects of carvedilol in the treatment of congestive heart failure complicating a- trial fibrillation. Methods 102 patients with congestive heart failure complicating atrial fibrillation treated from August 2006 to November 2011 were screened out and randomly divided into the carvedilol group （n=56） and the control group （n=46）. The control group was given the routine treatment including cardiac glycoside, diuretics, angiotensin-converting enzyme inhibitors according to the disease condition,while the carvedilol group was treated with carvedilol on the basis of the routine treatment （2.5-20.0 mg, twice a day）. Two groups were given 6-month treatment and follow up was performed at regular interval. The changes of clinical indicators before and after treatment were compared and the clinical efficacies were evaluated. Results The difference of the total effective rates between the two groups had statistical significance （P〈0.05）. The average ventricular rate after treatment in the carvedilol group was significantly lower than that in the control group with statistical difference （P〈0.05）. Conclusion Carvedilol can obviously improve the clinical symptoms and reduce the ventricular Tate in the patients with congestive heart failure complicating atrial fibrillation.