布地奈德联合异丙托溴胺治疗新生儿感染性肺炎疗效观察

Effective observation of budesonide combined with ipratropium bromide in treating neonatal infectious pneumonia

目的探讨布地奈德联合异丙托溴胺雾化吸入治疗新生儿肺炎的效果及安全性。方法将112例新生儿肺炎患者随机分为治疗组和对照组,治疗组58例,对照组54例。两组均给予抗感染、保暖、维持内环境稳定、必要时吸氧、机械通气辅助治疗等常规基础治疗,对照组采用生理盐水雾化吸入,治疗组采用布地奈德联合异丙托溴胺雾化吸入。观察记录鼻阻消失时间、呼吸困难好转时间、肺部啰音消失时间、总有效率、哭声嘶哑及鹅口疮发生情况等。结果治疗组鼻阻消失时间为(6.2±1.4)d,呼吸困难好转时间为(4.6±1.8)d,肺部啰音消失时间为(5.4±1.7)d;对照组鼻阻消失时间为(8.9±1.9)d,呼吸困难好转时间为(5.8±1.5)d,肺部啰音消失时间为(6.8±1.9)d,两组比较,差异有统计学意义(P<0.05)。治疗组哭声嘶哑发生率为5.17%(3/58),对照组为3.70%(2/54);治疗组鹅口疮发生率为3.45%(2/58),对照组为3.70%(2/54),两组比较,差异无统计学意义(P>0.05)。结论在新生儿肺炎的治疗中采用布地奈德联合异丙托溴胺雾化吸入辅助治疗效果显著,使用安全,值得临床推广应用。

Objective To discuss the effects and safety of budesonide combined with ipratropium bromide nebulization inhalation in treating neonatal pneumonia. Methods 1 I2 neonates suffering infectious pneumonia were randomly divided into the treatment group （n=58） and the control group （n=54）. Both groups were given the routine basic treatments including antin- fection, keeping warm,maintaining homeostasis,necessary oxygen inhalation and assisted mechanical ventilation. The control group received inhalation of aerosolized normal saline,while the treatment group received aerosol inhalation of budesonide com- bined with ipratropium bromide. To observe and record the time of rhinostegnosis disappearance, time of dyspnea improvement, time of lung tales disappearance,total effective rate,hoarse cry and thrush occurrence. Results In the treatment group, the time of rhinostegnosis disappearance was （6.2＋1.4）d, the time of dyspnea improvement was （4.6＋ 1.8 ）d and the time of lung rales dis- appearance was （5.4＋1.7）d;while in the control group, the time of rhinostegnosis disappeard was （8.9＋ 1.9 ）d, the time of dysp- nea improvement was （5.8~1.5）d and the time of lung rales disappearance was （6.8~1.9）d, the difference between the two groups showing statistical significance （P〈O.05）. The occurrrence rate of hoarse cry was 5.17% （3/58） in the treatment group and 3.70% （2/54） in the control group without statistically significant difference （P〉0.05）. The occurence rate of thrush was 3.45% （2/58） in the treatment group and 3.70% （2/54） in the control group without statistical differencebetween the two groups （P〉0.05）. Conclusion Adopting budesonide combined with ipratropium bromide is obviously effective and safe in the assisted treatment of neonatal pneumonia,which is worthy of promotion and application in clinic.