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Anexelekto与胃肠道肿瘤

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摘要 Anexelekto(Axl),又名Ark、Ufo或Tyr07,属于受体酪氨酸激酶家族,为大小约140ku的跨膜分子,定位于人的染色体19q13.1。Axl基因全长42185kb,由698个腺嘌呤、972个胞嘧啶、931个鸟嘌呤和626个胸腺嘧啶构成,包含20个外显子。研究显示,Axl激活与肿瘤的发生发展密切相关,在其增殖、凋亡及侵袭转移中发挥重要作用,抑制其活性对某些肿瘤治疗有一定疗效。
出处 《武警医学》 CAS 2013年第2期174-176,共3页 Medical Journal of the Chinese People's Armed Police Force
基金 上海交通大学医学院博士创新基金项目(BXJ201234) 国家自然科学基金项目(No.81272752)
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