2型糖尿病合并高尿酸血症与胰岛素抵抗、血脂及血压相关性的研究

Correlation of hyperuricemia with dyslipidemia,insulin resistance,and hypertension in T2DM patients

目的探讨T2DM合并高尿酸血症者与IR、脂代谢紊乱、高血压的相关性。方法纳入866例T2DM患者,按照SUA水平分为高尿酸血症(A)组和SUA正常(B)组,比较两组肾功能、血脂和胰岛素抵抗指数(HOMA-IR)。结果 T2DM患者中合并高尿酸血症的患病率为15.5%,A组BMI、DBP、TG、TC、极低密度脂蛋白胆固醇(VLDL-C)、Scr、HOMA-IR、尿微量白蛋白/肌酐(ACR)、动脉硬化指数(ASI)均高于B组,eGFR、ISI低于B组(P<0.05)。相关性分析显示,肾功能正常者中SUA与血脂、HOMA-IR和肾功能存在相关性。结论 T2DM患者高尿酸血症与血脂异常、IR、肥胖及高血压相关。

Objective To study the relationship of hyperuricemia with insulin resistance,dyslipidemia,and hypertension in T2DM patients.Methods The 866 T2DM patients were divided into the high uric acid（A） group（serum uric acid ≥ 420 μmol/L in male and ≥ 360 μmol/L in female） and the normal uric acid（B） group.Renal function,lipids,and insulin resistance index（HOMA-IR） were compared between the two groups.Results The prevalence of hyperuricemia was 15.5% in T2DM patients.BMI,SBP,TG,TC,very low-density lipoprotein cholesterol（VLDL-C）,Scr,HOMA-IR,albumin to creatinine ratio,and atherosclerosis index were all higher in the hyperuricemia group than in NUA group,while the glomerular filtration rate（eGFR） and ISI were higher in the NUC group than in HUA group（P0.05）.The result showed that the uric acid was correlated with lipids,insulin resistance,and renal function in normal renal function individuals.Conclusion Hyperuricemia is correlated with dyslipidemia,insulin resistance,obesity,and hypertension in T2DM patients.