含呋喃环双酰腙类化合物的合成与抗菌活性

Synthesis and antibacterial activities of bi-hydrazones with furan ring

以3,4-呋喃二羧酸为原料,经酯化、肼解合成3,4-呋喃二酰肼,再与芳香醛、酮类化合物发生缩合反应,合成6个含呋喃环双酰腙类化合物。通过1HNMR、FT-IR、MS对它们的结构进行了表征。研究了它们的抗菌活性,结果表明:6个化合物表现出良好的抗菌效果。

3,4-Furan di-acylhyrazines were prepared through esterification and hydrazinolysis of furan 3,4-dicarboxylic acid,and then react with aromatic aldehydes or ketones to yielded bi-hydrazones with furan ring.The structures were characterized by 1 HNMR,FT-IR and MS.All samples showed the good antibacterial activities.