无溶剂条件下SO_4^(2-)/ZrO_2催化α-呋喃丙烯酸酯的简便合成

A Convenient Method for Synthesis of α-Furanacrylates Catalyzed by SO_4^(2-)/ZrO_2 under Solvent-free Conditions

在无溶剂条件下,以SO24-/ZrO2作催化剂,糠醛与丙二酸发生Knoevenagel缩合得到α-呋喃丙烯酸,产物不经分离,直接与醇酯化合成了一系列α-呋喃丙烯酸酯。实验结果表明,在糠醛0.10mol,丙二酸0.10mol,醇0.13mol,催化剂0.96g,缩合反应1.5h,酯化反应2h的条件下,α-呋喃丙烯酸酯的产率为84.2%～96.1%,含量达99%以上。催化剂重复使用6次后,仍具有较高的催化活性。

A facile one-pot method for synthesis of α-furanacrylates via Knoevenagel condensation and es- terification from furaldehyde was achieved. The Knoevenagel condensation of furaldehyde with malonic acid on SO_4^2-/ZrO2 catalyst under solvent-free conditions first gave α-furanacrylic acid, which without sepa- ration reacted further with alcohols to form eight kinds of α-furanacrylates. When furaldehyde was 0.10 tool, malonic acid was 0.10 tool, alcohol was 0.13 tool, SO_4^2-/ZrO2 was 0.96 g, condensation time was 1.5 h, esterification time was 2 h, α-furanacrylates were obtained with 84.2%-96. 1%yield and more than 99%content. The catalyst was reused at least six times without significant decrease in activity.