摘要
对氨基苯酚是一种重要的医药、农药、染料中间体。以硝基苯为原料直接一步催化加氢合成对氨基苯酚具有成本低、收率高、三废排放少等优点,是一条绿色的合成路线。详细综述了硝基苯加氢生成羟基苯胺及羟基苯胺Bamberger重排生成对氨基苯酚的反应机理,加氢及重排催化剂研究等方面的研究进展,介绍了表面活性剂助剂对对氨基苯酚选择性及收率的影响。
p-Aminophenol (PAP) is an important intermediate for the synthesis of medicine, pesticide and dyestuff. Among the preparation routes of p-aminophenol, catalytic hydrogenation of nitrobenzene to p-a minophenol has some remarkable advantages, such as low production cost, high yield and friendliness to environment, therefore this process is a green synthesis route. Reviews the reaction mechanism of nitro- benzene to phenylhydroxylamine and the acid-catalysed Bamberger rearrangement of phenylhydroxylamine to p-aminophenol and the research progress of the study of hydrogenation and rearrangement. The influ- ence of adding surface active agent on selectivity and yield of p-aminophenol is also introduced.
出处
《化学世界》
CAS
CSCD
北大核心
2013年第2期122-124,128,共4页
Chemical World
基金
国家重点基础研究发展计划973项目(2009CB724701)
关键词
对氨基苯酚
硝基苯
加氢
催化剂
p-aminophenol
nitrobezene
hydrogenation
catalyst