鳞状细胞癌抗原、糖类抗原125检测在宫颈鳞癌中的应用价值

The Application Values Of Detection of SCC and CA125 In Squamous Cell Carcinoma of the Cervix

目的探讨肿瘤标志物鳞状细胞癌抗原(SCC)与糖类抗原125(CA125)检测在宫颈鳞状细胞癌中的应用价值。方法对经临床病理确诊的85例宫颈鳞状细胞癌患者、60例宫颈上皮内瘤样病变(CIN)患者以及45例健康妇女,采用雅培微粒子免疫分析仪IMX和罗氏电化学发光分析仪E170分别检测血清SCC和CA125数值,比较分析二者改变的临床意义。结果与正常对照组及CIN组相比,宫颈鳞癌组治疗前血清SCC水平及阳性率均较高(P<0.05);而CA125在三组间无统计学差异(P>0.05)。在国际妇产科联盟(Federation International of Gynecology andObstetrics,FIGO)分期中,SCC水平及阳性率随分期上升而增加(P<0.05);而CA125仅浓度改变有统计学差异(P<0.05)。SCC和CA125在不同病理分级中均无显著改变(P>0.05)。宫颈鳞癌患者治疗前后的血清SCC改变,差异有统计学意义(P<0.05);而血清CA125无统计学差异(P>0.05)。结论 SCC测定可作为宫颈鳞癌诊断的辅助指标,用于病情进展、治疗效果的监测。而CA125在宫颈鳞癌诊疗中的意义不大,二者联合检测可以提高对宫颈鳞癌诊断的敏感性。

Objective To study the clinical value of squamous cell carcinoma associated antigen（SCC） and CA125 in the diagnosis and monitoring of squamous cell carcinoma of the cervix. Methods The samples of peripheral venous blood from 85 patients with cervix squamouscell carcinoma, 60 patients with cervical intraepithelial neoplasia（CIN） and 45 healthy women were collected. Then the serum SCC was measured by IMX, and CA125 was measured by Roche E170. Results The levels and positive rates of SCC were significantly higher than those in the other groups（P〈0.05）, but the levels and positive rates of CA125 were not variable. With the increasing of FIGO stage, the levels and positive rates of SCC and the levels of CA125 increased significantly （P〈0.05）. The post-treatment SCC level was significantly lower than that of pretreatment （P〈0.05）. But CA125 level was not variable. Both SCC and CA125 did not change with the pathological grades significantly. Conclusion SCC contributes to the diagnosis of cervix squamous cell carcino ma and observing therapeutic efficacy. CA125 is not so helpful for cervix squamous cell carcinoma in the diagnosis and observing therapeutic efficacy. The combined determination can improve the diagnostic sensitivity.