副猪嗜血杆菌毒力因子研究进展

Progress on Virulence Factors in Haemophilus parasuis

副猪嗜血杆菌(Haemophilus parasuis)是引起猪革拉泽氏病(Glsser’s disease)的病原,能在特定的条件下侵入机体而引起严重的全身性疾病,以纤维素性多发性浆膜炎、关节炎和脑膜炎为主要特征。副猪嗜血杆菌的毒力因子仍不十分清楚。H.parasuis的全基因组测序工作的完成和遗传操作系统的建立极大促进了毒力因子、致病机制和基因功能的研究。近年证实了H.parasuis的外膜蛋白(Omp)和脂多糖(LPS)与毒力有一定的联系,特别是OmpP2、OmpP5和LPS的庚糖基转移。为了进一步鉴定毒力因子,利用在体外模拟体内感染环境和比较基因组学等方法鉴定了H.parasuis潜在的毒力因子。论文对H.pa-rasuis的毒力因子进行综述,以供参考。

Haemophilus parasuis, a commensal organism of the upper respiratory tract of pigs, can invade the host and cause severe systemic disease characterized by fibrinous polyserositis, arthritis, and meningi tis, known as Glfisser＇s disease. However, the virulence factors were largely unknown. The H. parasuis genome sequence was completed and the efficient genetic manipulation has been developed in H. parasuis, which greatly facilitate to study the gene function, virulence factors and pathogenesis mechanisms. Recently, it confirmed that outer membrane proteins and lipopolysaccharide have a certain relation with the virulence in H. parasuis, especially to OmpP2, OmpP5 and heptosyltransferase of LPS. Furthermore, many potential virulence-associated factors of H. parasuis have been identified in vitro studies either mimic those encountered during an infection or comparative genomic analysis. In this review, the current knowledge of the virulence factors in H. parasuis was reviewed.