联合检测抗CCP抗体和RF在类风湿关节炎中的诊断价值

Clinical value of combined detection of RF and anti-CCP antibody in diagnosis of rheumatoid arthritis

目的评价抗环瓜氨酸(CCP)抗体在类风湿关节炎(RA)诊断中的价值。方法用ELISA法检测87例RA患者及69例其他自身免疫性疾病患者(对照组)血清中的抗CCP抗体浓度,用免疫透射比浊法检测类风湿因子(RF)浓度。以36例同期健康体检者作为健康对照组。比较抗CCP抗体和RF对RA诊断的敏感度及特异度。结果抗CCP抗体的敏感度为60.9%,RF为67.2%,差异无统计学意义(P>0.05)。抗CCP抗体的特异度为94.2%,RF为72.5%,差异有统计学意义(P<0.05)。两者联合检测特异性为97.1%。结论抗CCP抗体在RA诊断中具有较高的特异性,可作为诊断RA的理想血清学指标。两者联合检测可提高检测的特异度。

Objective To evaluate the clinical value of anti-cyclic citrullinated peptide（CCP） antibody in the diagnosis of rheu-matoid arthritis（RA）. Methods 87 cases of patients with RA and 69 cases of patients with other autoimmune diseases（control group） were detected for serum anti-CCP antibody by ELISA and for RF by turbidimetry method. 36 healthy subjects were en-rolled as healthy control group. Diagnostic sensitivity and specificity of anti-CCP antibodies and RF in RA were compared. Results The sensitivity of anti-CCP antibody was 60.9% ,of RF was 67.2% and there was no significant difference between them（P〉0.05）. The specificity of anti- CCP antibody was 94.2% ,of RF was 72.5% ,and the difference was significant（P〈0.05）. The spe-cificity of combined detection of anti-CCP antibody and RF was 97.1%. Conclusion Anti-CCP antibody might be with high spe-cificity for the diagnosis of RA,and could be an ideal serologicial index for the diagnosis of RA. Combined detection of anti-CCP antibody and RF could increase the diagnostic specificity.