孕产妇6种病原体感染的血清标志物检测及其临床意义

Significance of 6 pathogens detected in pregnant woman

目的了解该地区孕产妇乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)及TORCH(弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)和单纯疱疹病毒(HSV))的感染情况,并探讨孕产妇感染性血清标志物检测的临床意义。方法对2011年1～12月该院门诊和住院的2535例孕产妇进行产前乙型肝炎表面抗原(HBsAg)、HCV抗体(抗-HCV)及TORCH特异性抗体IgM检测。结果 2535例孕产妇中,HBsAg、抗-HCV、TOX-IgM、RV-IgM、CMV-IgM及HSVⅡ-IgM阳性率分别为12.5%、0.67%、1.74%、2.68%、0.55%及0.16%。结论本地区孕产妇以HBV感染为主,此6种病原体可垂直传播导致新生儿先天缺陷,通过对孕产妇进行感染性血清标志物检测,是及早发现传染病和防止母婴垂直传播的有效防治措施之一,对减少新生儿传染病的发生,提高优生优育和人口素质尤为重要。

Objective To investigate the infection situation of hepatitis B virus（HBV）, hepatitis C virus（HCV） and TORCH,in-cluding Toxoplasma gondii（TOX）, rubella virus（RV）, cytomegalovirus（CMV） and herpes simplex virus（ HSV）, in pregnant women of the area. Methods In 2011,2 535 cases of pregnant women in the hospital were detected surface antigen（HBsAg） for HBV, HCV antibody（anti-HCV） and TORCH IgM antibody. Results In 2 535 cases of pregnant women,positive rates of HBsAg,anti-HCV,TOX-IgM,RV-IgM,CMV-IgMand HSV Ⅱ-IgM were 12.5%,0.67%,1.74%,2.68%,0.55% and 0. 16%, respectively. Conclusion HBV might be the main infection disease in pregnant women in the region. Vertical transmission of 6 pathogens could cause birth defects in newborns. Detection of maternal serum markers of infection might be useful for early detection of infectious diseases, be effective for prevention of vertical transmission, reducing the incidence of neonatal infectious diseases, improving the prenatal and postnatal care and the quality of population.