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喷司他丁的纯化工艺研究 被引量:1

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摘要 目的通过对喷司他丁纯化工艺研究,提高产品质量。方法对喷司他丁的纯化液采用强碱性阴离子交换树脂进行处理,提高组份含量比例。结果采用强碱性阴离子交换树脂处理后,喷司他丁的HPLC组份纯度比率平均提高59%。结论采用新的离子树脂纯化工艺对喷司他丁的纯度有明显提高,并且工艺稳定性好,重现性高,可适用于工业化生产。
作者 邹昕
出处 《海峡药学》 2013年第1期25-27,共3页 Strait Pharmaceutical Journal
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  • 1崔莹.液相色谱柱的使用与维护[J].分析仪器,2006(3):53-56. 被引量:7
  • 2高丽萍,吴平东,Liu Meizheng.高效液相色谱法分离和分析喷妥司汀及其异构体[J].分析化学,2006,34(11):1603-1606. 被引量:5
  • 3Woo P W K, Dion H W, Lange S M, L F. , et al. A novel adenosine and araA deaminase inhibitor 3 - (2' - deoxy - β - - D - eiythropentofuranosyl - 3,6,7,8 - tetrahydro - imidazo(4,5 - d) ( 1, 3 ) diazepin - 8 [ J ]. J. neterocycli. Chem. 1974,11,641 - 643.
  • 4Daddona P E. Human adenosine deaminase. Properties and turnover in cultured T and B lymphoblasts [ J ]. J. Biol. Chem. 1981,256,12496 - 12501.
  • 5Kasibhatla S R, Bookser B C, Xiao W, Erion M D. AMP deaminase inhibitors. 5. Design, synthesis and SAR of a highly potent inhibitor series [ J ]. J. Med. Chem. 2001,44, 613 -618.
  • 6Kasibhatla S R, Erion M D. AMP deaminase inhibitors. 2. Initial discovery of a non- nucleotide transition- stateinhibitor series[ J]. J. Med. Chem. 2000,43,1519.
  • 7Erion M D, Kasibhatla S R, Bookser B C, Appleman J R. CycloSal - pronucleotides of 2',3'- dideoxyadenosine and 2', 3'- dideoxy - 2',3'- didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system[J]. Am. Chem. Soc. 1999,121,308-319.
  • 8Chen W, Hoerter J, Gueron M. A comparison of AMP degradation in the perfused rat heart during 2 - deoxy - d - glucose perfusion and anoxia. Part Ⅰ: The release of adenosine and inosine[ J]. J. Mol. Cell. Cardiol. 1996,28,2163-2174.
  • 9Albert Ryder, Henry W Dion, Peter W Woo, John D Howells. Use of adenosine deaminase inhabitores to treat systemic inflammatory resonse sydrome [ P ]. U. S Patent 3923785 ; 10.25. 1975.
  • 10French J C, Mich A A. Process for purifying pentostatin [P]. U. S Patent 5463035; 10.31. 1995.

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