老年原发性高血压合并非乙醇性脂肪肝的患病情况及危险因素分析

Clinical analysis of non-alcoholic fatty liver disease in older essential hypertension patients

目的探讨老年高血压患者非乙醇性脂肪性肝病的患病率和危险因素。方法 621例老年高血压患者住院期间经腹部超声检查和采集病史筛查非乙醇性脂肪性肝病(NAFLD),观察其患病率、肝功酶学异常的比例及其危险因素。结果 NAFLD患者发病率为39.1%(243/621)。NAFLD组糖尿病,冠心病,代谢综合征发生率、超重率、三酰甘油、ALT水平高于非NAFLD组,HDL-C低于非NAFLD组,差异有统计学意义(P<0.05)。糖尿病、冠心病、超重和三酰甘油水平是老年高血压患者NAFLD的独立危险因素。结论老年高血压伴NAFLD患者与代谢综合征等多代谢异常密切相关。

Objective To investigate the incidence of non-alcoholic fatty liver disease（NAFLD） in older patients with essential hypertension and the relationship between NAFLD and risk factors.Methods 621 older patients with essential hypertension were enrolled into this study.All patients had ultrasound screening for fatty liver.Results Among 621 recruited patients,39.1%（243/621） had fatty liver by ultrasonography.In essential hypertension（EH） together with NAFLD group,the prevalences of diabetes mellitus,coronary artery disease,metabolic syndrome,overweight,and the level of TG or ALT were significantly higher than those in the EH alone（P0.05）.HDL-C was significantly lower than that in the EH alone（P0.05）.By multivariable logistic regression analysis,diabetes mellitus,coronary artery disease,overweight and TG were risk factors of NAFLD in older patients with essential hypertension.Conclusion Non-alcoholic fatty liver disease is more prevalent in older patients with essential hypertension complicated with multiple metabolic disorders.