甲胎蛋白与α-L-岩藻糖苷酶联合诊断原发性肝癌

Value of combined detection of the multi-markers to early diagnose primary hepatic carcinoma

目的探讨甲胎蛋白(AFP)与α-L-岩藻糖苷酶(AFU)两项肿瘤标志物在原发性肝癌的实验室诊断中的临床应用价值。方法选择原发性肝癌60例、转移性肝癌30例、慢性肝炎肝硬化60例及健康对照60例,进行AFP与AFU联合血清检测,纳入临床分析。结果原发性肝癌患者在不同的AFP检测阈值下,肝癌诊断的敏感性随阈值下降而上升,同时特异性却在下降。AFU可敏感而特异的检出原发性肝癌,特别是小肝癌,显示良好的诊断效率(检出率达89.6%)。AFP与AFU联合检测PHC,总的阳性率可达96.49%。结论联合应用AFP和AFU可提高小肝癌的检出率,减少漏诊误诊,具有较大的临床价值。

Objective To evaluate the clinical implication of the AFP and the alpha-l-rock algae glycosidases（AFU）in the laboratory diagnosis of primary hepatic cancer.Methods 60 cases of primary liver cancer,30 cases of liver metastases,and 60 cases of liver cirrhosis were enrolled in the study and 60 healthy volunteers were also enrolled as normal control.Serum AFP and AFU were tested in all the participants.Results The sensitivity and specificity of AFP in the diagnosis of Primary liver cancer were significantly influenced by the threshold used for the assay,the higher the threshold,the lower the sensitivity and higher the specificity.AFU was more sensitive in the detecting the primary hepatic cancer while maintaining high specificity at same time.Conclusion The adoption of serum AFU and AFP can improve the clinical screening and diagnosis of primary hepatic cancer and greatly facilitate the early diagnosis and treatment.