2型糖尿病患者外周动脉病变对慢性肾脏病发病的预测研究

Relationship between Peripheral Arterial Disease and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus

目的:探讨T2DM患者中外周动脉病变(PAD)及慢性肾脏病(CKD)发病的相关性。方法:对本院2009年1月-2011年12月期间308例T2DM住院患者进行横断面研究,患者根据是否存在PAD进行成组配比病例对照研究,据两组资料行单因素、多因素非条件logistic回归分析。结果:所有患者中,CKD患者的比例为36.4%,37.9%的患者有微量白蛋白尿。与对照组相比,PAD(ABI<0.9)糖尿病患者CKD的患病率更高。CKD和微量白蛋白尿是PAD的独立危险因素,其优势比分别为1.624,2.002。结论:T2DM患者CKD和微量白蛋白尿与PAD的发生独立相关,在具有CKD及微量白蛋白尿的T2DM人群中并发PAD的比例增加,应对这一高危人群进行PAD的进行早期诊断及治疗。

Objective： The aim of this study was to discuss the relationship between PAD and chronic kidney disease （ CKD ） in patients with type 2 diabetes mellitus （ T2DM ） because of diagnosing peripheral arterial disease （ PAD ） and recognizing its associated risk factors in diabetes is important due to high risk of cardiovascular disease and limb loss. Method： 308 patients with T2DM were collected from January 2009 to December 20tl in our hospital, We examined the cross-sectional association of PAD, and single variable, multiple variable analysis and interaction item were done by using non-conditional logistic regression.Result： The prevalence of CKD was greater in patients with PAD compared to controls （ P〈0.05 ） .The association of PAD with CKD （ OR 1.624, 95 % CI 1.316-1.851, P〈0.05 ） and Microalburminuria （ OR 2.002, 95 % CI 1.754-6.727, P〈0.05 ） were dependent risk factors of PADinT2DM patients. Conclusion： In patients with T2DM, reduced GFR and microalburminuriaare associated indenpendently with PAD.Their combined presence characterized a subgroup of population who have an elevated prevalence of PAD and could benefit from early diagnosis and treatment.