抑郁症患者儿童期受虐对5-羟色胺水平的影响

Effects of childhood abuse on 5-HT levels of depression patients

目的探讨抑郁症患者儿童期受虐对血清5-羟色胺水平的影响。方法对101例抑郁症患者采用儿童受虐问卷、汉密顿抑郁量表、自杀意念量表及Beck绝望量表评定儿童期受虐状况、抑郁严重程度、自杀意念强度和绝望严重程度；根据儿童受虐问卷评分将受试者分为受虐组（50例），无受虐组（51例）。采用酶联免疫吸附法测定血清5-羟色胺水平。结果101例抑郁症患者中，49．5％在儿童期有过不同类型不同程度的受虐，其中情感虐待45．5％，情感忽视27．7％，躯体虐待24．8％，躯体忽视56．4％，性虐待18．8％。受虐组汉密顿抑郁量表总分显著高于无受虐组（P〈0．05）。受虐组的血清5羟色胺水平显著低于无受虐组（P〈0．05），其中情感受虐组低于无受虐组（P〈0．05）。血清5羟色胺水平与汉密顿抑郁量表总分和情感虐待评分呈显著负相关（R=-0．25、-0．21，P〈0．05）。结论抑郁症患者儿童期受虐待对5-羟色胺水平有明显的影响，儿童期受虐可能是成年后罹患抑郁症的危险因素。

Objective To explore the effects of childhood abuse on 5-HT levels of depression patients. Methods Childhood abuse status, depression severity, suicide idea intensity and hopelessness severity were assessed with the Childhood Trauma Questionnaire （CTQ）, Hamilton Depression Rating Scale （HAMD）, Self-rating Idea of Suicide Scale （SIOSS） and Beck Helpless Rating Scale （BHS） among 101 depression patients; according to CTQ score subjects were divided into abuse group （n= 50） and non-abuse group （n=51）. 5HT levels were determined using the Enzyme Linked Immunosorbent Assay. Results Of 101 depression patients 49.5% had different degrees of maltreatment in childhood, among maltreated ones 45.5% suffered emotional abuse, 27.7% emotional neglect, 24.8% physical abuse, 56.4% physical neg- lect and 18.8% sexual abuse. The total score of the HAMD was significantly higher in abuse than non-a- buse group （P〈0.05）. 5-HT levels were significantly lower in abuse than non-abuse group （P〈0.05） and in emotional abuse than in non-emotional group （P〈0.05）. 5-HT levels were negatively related to the total score of the HAMD and emotional abuse score significantly （R= -0.25, -0.21, P〈0.05）. Con- clusion Childhood abuse influences 5-HT levels of depression patients notably and may be a risk factor of adult depression development.