心房颤动患者幽门螺杆菌感染与胱氨酸蛋白酶抑制剂C、血脂的关系

Relationship between helicobacter pylori infection and serum cystatin C, blood-lipoids in patients with atrial fibrillation

目的探讨心房颤动患者幽门螺杆菌(Hp)感染与胱氨酸蛋白酶抑制剂C(Cyc)、血脂水平变化的相关性。方法选择53例心房颤动患者为研究对象,另选择55例体检者为对照组。分别采用酶联免疫吸附法(ELISA)以及免疫比浊法检测Hp特异性抗体IgG(Hp IgG)和Cyc表达水平,并检测血脂水平,分析Hp感染与血脂、血清Cyc表达变化之间的关系。结果心房颤动组Hp IgG阳性率与对照组比较,差异无统计学意义(χ2=2.53,P>0.05);血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、Cyc的表达水平均明显高于对照组,高密度脂蛋白胆固醇(HDL-C)表达水平明显低于对照组,差异均有统计学意义(t分别=6.92、5.41、6.75、3.90、-3.11,P均<0.05);Hp感染阳性的心房颤动患者的血清TC、TG、LDL-C、Cyc表达水平均明显高于Hp感染阴性患者,而HDL-C表达水平明显低于Hp感染阴性患者,差异均有统计学意义(t分别=5.66、6.13、7.04、4.75、-4.39,P均<0.05)。结论 Hp感染与心房颤动本身的发生没有明显相关性,但Hp感染可能通过对血脂代谢和Cyc表达水平的影响而促进心房颤动的发展和演进。

Objective To explore the relationship between helicobacter pylori infection and blood-lipoids,cystatin C （Cyc） of atrial fibrillation （AF）. Methods A total of 53 patients with atrial fibrillation were selected as AF group and 55 health people as control group. Serum specific antibodies to Hp（HpIgG）, Cyc and serum lipids were measured and the relationship between Hp and the expression of serum Cyc, blood-lipoids were analyzed. Results The positive rate of HpIgG in the the AF group had no statistical significance compared with the control group （X^2=2.53,P〉0.05）. The levels of serum TC,TG,LDL-C and Cyc in the AF group were higher than those in the control group （t=6.92,5.41,6.75,3.90,P〈0.05）. The level of serum HDL-C in the AF group was lower than that in the control group （t=-3.11 ,P〈0.05）. Those who had positive HpIgG had significantly higher levels of TC,TG,LDL-C and Cyc than those whose HpIgG were negative （t= 5.66,6.13,7.04,4.75,P〈0.05） while level of HDL-C was lower（t=-4.39,P〈0.05）. Conclusions There is no significant correlation betwen Hp infection and AF. Hp infection may promote the evolution of AF through influencing the blood lipid metabolism and the Cyc level.