EV71型手足口病患儿体液免疫功能分析

Analysis on function of humoral immunity in children with hand-foot-mouth disease by EV71 infection

目的探讨不同程度EV71感染手足口病患儿的体液免疫功能。方法采集37例EV71感染的手足口病患儿,包括皮肤黏膜型20例、神经系统损害型17例。以同期22例正常儿童为对照,分别测定血清IgG、IgA、IgM及补体C3、C4水平。结果与正常对照组相比,皮肤黏膜型及神经系统受累型两组的血清IgG、IgA水平明显降低(t分别=2.18、2.45、2.58、3.29,P均<0.05),而IgM水平明显升高(t分别=2.44、2.28,P均<0.05),C3、C4水平无明显差异(F分别=1.38、0.48,P均>0.05)。皮肤黏膜型和神经系统受累型的患儿IgG、IgA、IgM比较,差异均无统计学意义(t分别=0.55、1.05、0.34,P均>0.05)。结论 EV71感染的手足口病患儿的体液免疫应答存在异常,但与感染后病情轻重及不同临床转归无明显关系。

Objective To study the function of humoral immunity in children with hand-foot-mouth disease（HFMD） in different severity. Methods Levels of IgG, IgA, IgM and C3, C4 were detected in 37 children with HFMD by EV71 infection who were divided into two groups ： skin and mucous membrane and central nervous system involved. Levels of IgG, IgA, IgM and C3, C4 of children with HFMD were compared with those of 22 normal controls. Results Serum levels of IgG, IgA were significantly reduced compared with those of the normal control（t=2.18,2.45,2.58,3.29, P〈0.05 ）while levels of IgM was obviously increased（t=2.44,2.28 ,P〈0.05）. There were no significant differences in C3 and C4 between two groups（F=1.38,0.48,P〉0.05）. There were no significant differences in IgG, IgA, IgM between skin and mucous membrane involvement and central nervous system involvement group （t=0.55,1.05,0.34,P〉0.05）. Conclusions The hnmoral immune response was abnormal in children with HFMD by EV71 infection, however, which might had no significant relationship with the severity of infection and different clinical outcomes.