壳聚糖宫颈抗菌膜联合多西环素治疗非淋菌性宫颈炎的疗效分析

Therapeutic effect of chitosan cervical antibacterial membrane combined with doxycycline for nongonococcal cervicitis

目的探讨壳聚糖宫颈抗菌膜治疗持续性宫颈炎的疗效。方法 147例非淋菌性宫颈炎患者采用口服多西环素连续治疗14d停药,观察6周后复查病原体转阴性仍表现持续性宫颈炎的70例患者,随机分为治疗组和对照组,各35例,其中治疗组予壳聚糖宫颈抗菌膜治疗,每周1次,连用8周,对照组仅随访观察,10周后评估转归结果。结果 (1)非淋菌性宫颈炎在接受多西环素治疗后,有47.62%患者病原体检测阴性但表现为持续性宫颈炎。(2)持续性宫颈炎观察组痊愈10例、显效14例、有效9例、无效2例,总有效率94.29%;而对照组痊愈、显效、有效和无效例数分别为0、0、2和33例,总有效率5.71%。(3)壳聚糖宫颈抗菌膜治疗过程未发现明显不良反应。结论壳聚糖宫颈抗菌膜治疗持续性宫颈炎是一种安全、有效的新治疗方法。

Objective To explore the therapeutic effect of chitosan cervical antibacterial membrane combined with doxycycline for persistent cervicitis. Methods 147 cases of nongonococcal cervicitis were treated with oral doxycycline for 14 consecutive days. After 6 weeks,70 cases showed no evidence in pathogen detecting for nongonococcal cervicitis. But all the 70 cases still had clinical manifestation of nongonococcal cervicitis. They were divided into observing group and control group （n= 35）. Patients in observing group were treated chitosan cervical antibacterial membrane,once a week for 8 weeks. Results 47.62% of patients with nongonococcal cervicitis showed no evidence in pathogen detecting after treatment of oral doxycycline. Total effective power was 94.29 % for observing group as well as 5.71% for control group. There was no obvious adverse reaction for using of chitosan cervical antibacterial membrane. Conclusion Chitosan cervical antibacterial membrane is safety and effective for treating persistent cervicitis.