吲达帕胺联合氨氯地平治疗高血压合并冠心病患者的疗效观察

Curative effect of indapamide combined with amlodipine in treatment of hypertension associated with coronary heart disease

目的观察吲达帕胺联合氨氯地平片治疗高血压合并冠心病的临床疗效。方法选择该院收治的高血压合并冠心病患者68例,随机分为治疗组40例、对照组28例。治疗组给予苯磺酸氨氯地平片和吲达帕胺缓释片,对照组给予硝苯地平控释片,治疗6周后,分别观察两组血压、硝酸甘油片用量、血脂及不良反应情况。结果治疗组降压及硝酸甘油片用量减少总有效率均高于对照组(χ2分别为4.31和11.5,P<0.05);治疗组血脂含量的变化均优于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论吲达帕胺联合氨氯地平片治疗高血压合并冠心病的临床疗效良好,能有效控制病情,值得临床推广应用。

Objective To observe the efficacy of indapamide combined with amlodipine in treatment of hypertension associated with coronary heart diseas. Methods 68 patients treated in our hospital from December 2010 to March 2012 were divided into treatment group（40 cases） and control group （28 cases）. The treatment group was given amlodipine besylate tablets and indapamide sustained-release tablets,and the control group was given nifedipine controlled release tablets. After treatment for 6 weeks, the blood pressure, nitroglycerin tablet dosage, blood fat and adverse reaction were observed in two groups. Results Total effective rate of an- tihypertensive in treatment group was significantly greater than that in the control group,and nitroglycerin tablet dosage obviously reduced （X^2 = 4.31 and 11.5, respectively, P〈0.05）. Change of blood fat content in treatment group was better than that in control group （P〈0.05）. There was no obvious difference in adverse reaction rate between the two groups（P〉0.05）. Conclusion The efficacy of indapamide combined with amlodipine in treatment of hypertension associated with coronary heart disease is good. It can control the patient＇s condition effectively,and is worth to be popularized and appticated widely.