重组人脑利钠肽改善大鼠急性心肌梗死后心功能的实验研究

The Study of rBNP Improving Cardiac Function of Rat After Acute Myocardial Infarction

目的观察重组人脑利钠肽能否改善大鼠急性心肌梗死后的心功能。方法应用开胸结扎的方法制备大鼠急性心肌梗死模型,将制备成功的模型随机分为二组,Ⅰ组为重组人脑利钠肽组(n=20),每只大鼠按0.01μg/kg.min-1持续泵人重组人脑利钠肽24 h,Ⅱ组为对照组(n=20),每只大鼠泵入同等剂量的生理盐水持续24 h,而后正常饲养大鼠。在急性心肌梗死6周后采用超声心动图检查各组大鼠的心脏功能,记录结果并进行统计分析以观察两组间是否有差异。结果重组人脑利钠肽组大鼠的各项超声指标均优于对照组。结论重组人脑利钠肽可改善大鼠急性心肌梗死后的心脏功能。

Objective To observe recombinant human B-type natriuretic peptide （rBNP）can or not improve cardiac function after acute myocardial infarction （AMI）. Methods The model of AMI of rat is set up by coronary artery ligation. The successful model is divided into two group. The first is rBNP group（ n = 20） in which every rat is injected persistently into rBNP for 24 h （0.01 μg/kg ·min^-1）. The second is the control group in which every rat is injected into normal sodium for 24 h（0.01 μg/kg ·min^-1）. Then two groups of rats are breed routinely. Cardiac function is tested by echocardiograph 6 weeks after AMI, the date is recorded to analysis the difference between two groups. Results The ultrasonic indexes of rBNP group is superior to control groups. Conclusion rBNP can improve the cardiac function of rat after AMI.