摘要
干细胞是各种成熟细胞的起源细胞,具有自我增殖和分化的潜能,能修复或替代受损组织和器官的生物学功能。用于心肌修复的干细胞包括同种异基因干细胞和自体同源性干细胞(成体干细胞)两大类。干细胞移植理论上可治疗扩张型心肌病、急性心肌梗死等心脏疾病。干细胞移植的途径有外周静脉注射、经心外膜直视下注射、经冠状动脉注射、心内膜注射等。该技术的应用使临床受益很大,与此同时也存在一些问题,如移植细胞种类及数量的选择,移植后的安全性问题等,目前该学科尚在进一步研究中。
Stem cells are origin cells of various mature cells,with the potential of self-renewal and differentiation.Stem cells have a strong regenerative capacity to replace,repair or strengthen damaged tissues or organs of biological functions.Two types of stem cell are used for cardiac repairing,i.e.allogene stem cell and somatic stem cell.In theory,it can cure dilated cardiomyopathy and acute myocardial infarction.The ways of stem cell transplantation are intravenous injection,epicardium injection,injection of coronary artery,and endocardium injection.The technology bring considerable benefit to the clinical practice,while there are still some problems to be solved,such as transplantation cell type and quantity,and post transplantation safety,which is still in further studies.
出处
《医学综述》
2013年第3期410-414,共5页
Medical Recapitulate
